学术动态
国际著名风湿病杂志（Ann Rheum Dis）上刊载了一篇有意思的论文。作者观察到在同样的遗传背景下，女性强直性脊柱炎病人母乳喂养的机会明显少于没有强直性脊柱炎的健康人，特别是得强直性脊柱炎的病人较其健康的兄弟姐妹母乳喂养的机会较少，母乳喂养可能是减少后代得强直性脊柱炎的较好方法。
作者推测有可能是母乳喂养更有利于建立健康的肠道微环境，而肠道菌群为主的肠道微环境在强直性脊柱炎的发病和病情进展中具有重要作用。这一消息对于准备孕育下一代的病友应该是一个非常有价值的信息。
原文摘要
Objective:Ankylosing spondylitis （AS） is a chronic inflammatory disease affecting the spine and pelvis of young adults. On the HLA-B27 genetic background, the occurrence of AS is influenced by the intestinal microbiota. The goal of our study was to test whether breast feeding, which influences microbiota, can prevent the development of AS.
Methods: First, 203 patients with HLA-B27-positive AS fulfilling the modified New York criteria were recruited in the Department of Rheumatology, Ste Marguerite hospital in Marseilles. A total of 293 healthy siblings were also recruited to make up a control group within the same families. Second, 280 healthy controls, and 100 patients with rheumatoid arthritis and their siblings were recruited. The data collected were age, gender, number of brothers and sisters, age at disease onset, type and duration of feeding （breast or bottle）。
Results: Patients with AS had been breast fed less often than healthy controls. In families where children were breast fed, the patients with AS were less often breast fed than their healthy siblings （57% vs 72%）， giving an OR for AS onset of 0.53 （95% CI （0.36 to 0.77）， p value=0.0009）。 Breast feeding reduced familial prevalence of AS. The frequency of breast feeding was similar in the AS siblings and in the 280 unrelated controls. However, patients with AS were less often breast fed compared with the 280 unrelated controls （OR 0.6, 95% CI （0.42 to 0.89）， p<0.01）。
Conclusions: Our study suggests a breastfeeding-induced protective effect on the occurrence of AS. To our knowledge, this is the first study of breastfeeding history in patients with AS.
